Set in 2213, Perpetuum, or rather the Perpetuum Project, represents the Syndicate's (a conglemerate of Earth's largest corporations) incursion onto Nia, an alien planet inhabited by synthetic beings. By way of a - accidentally discovered - microscopic wormhole, Earth-based agents are able to remotely take over these lifeforms, as the result of an human-developed virus.

Release of the virus ensured the Syndicate a small foothold on Nia, but it's spread was halted. It's your job, as an agent employed by the Syndicate, to ensure a more permanent foothold. Build up your industry, stockpile weaponry, and expand and maintain your operations on the outlying territories.